An efficient synthesis of 4H-chromene, 4H-pyran, and oxepine derivatives via one-pot three-component tandem reactions
A new and efficient method has been developed for the synthesis of highly functionalized 2-amino-4H-pyran, 2-amino-4H-chromene, 2-amino-oxepine, and 2-hydroxy-oxepine derivatives through one-pot, three-component tandem reactions of structurally diverse 1,3-diketones, dialkyl acetylenedicarboxylates,...
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| Veröffentlicht in: | Tetrahedron letters 2012-12, Vol.53 (51), p.6977-6981 |
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| creator | Kazemi, Bagher Javanshir, Shahrzad Maleki, Ali Safari, Mostafa Khavasi, Hamid Reza |
| description | A new and efficient method has been developed for the synthesis of highly functionalized 2-amino-4H-pyran, 2-amino-4H-chromene, 2-amino-oxepine, and 2-hydroxy-oxepine derivatives through one-pot, three-component tandem reactions of structurally diverse 1,3-diketones, dialkyl acetylenedicarboxylates, and malononitrile or ethyl cyanoacetate in the presence of a catalytic amount of Na2CO3 in ethanol. This efficient technique has the advantages of giving products in good to high yields, in short reaction times, and with a simple isolation procedure. |
| doi_str_mv | 10.1016/j.tetlet.2012.10.046 |
| format | Article |
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| ispartof | Tetrahedron letters, 2012-12, Vol.53 (51), p.6977-6981 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Cascade chemical reactions Catalysis Chromene Derivatives Dialkyl acetylenedicarboxylate Ethanol Ethyl alcohol Malononitrile Multicomponent reaction Oxepine Pyran Reaction time Synthesis (chemistry) Tetrahedrons |
| title | An efficient synthesis of 4H-chromene, 4H-pyran, and oxepine derivatives via one-pot three-component tandem reactions |
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