An efficient and convenient synthesis of 1,2,3-trisubstituted pyrroles via iodocyclization from ethyl acetoacetate

A novel and efficient methodology for the synthesis of 1,2,3-trisubstituted pyrroles by one-pot two-step reaction has been developed. The iodocyclization of a series of β-enamino esters followed by dehydroiodination, led to the formation of corresponding pyrroles. This approach provides an easy acce...

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Veröffentlicht in:	Tetrahedron letters 2013-06, Vol.54 (23), p.2929-2933
Hauptverfasser:	Xu, Pengfei, Huang, Kunzhu, Liu, Zhiguo, Zhou, Ming, Zeng, Wenbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Esters Formations Iodocyclization Methodology One-pot synthesis Pyrroles Synthesis (chemistry) Tandem reaction Tetrahedrons
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creator	Xu, Pengfei Huang, Kunzhu Liu, Zhiguo Zhou, Ming Zeng, Wenbin
description	A novel and efficient methodology for the synthesis of 1,2,3-trisubstituted pyrroles by one-pot two-step reaction has been developed. The iodocyclization of a series of β-enamino esters followed by dehydroiodination, led to the formation of corresponding pyrroles. This approach provides an easy access to a wide range of 1,2,3-trisubstituted pyrroles.
doi_str_mv	10.1016/j.tetlet.2013.03.094
format	Article
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subjects	Esters Formations Iodocyclization Methodology One-pot synthesis Pyrroles Synthesis (chemistry) Tandem reaction Tetrahedrons
title	An efficient and convenient synthesis of 1,2,3-trisubstituted pyrroles via iodocyclization from ethyl acetoacetate
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