Synthesis and anti-HCV activity of 1-(1′,3′-O-anhydro-3′-C-methyl-β-d-psicofuranosyl)uracil

[Display omitted] Synthesis of a novel 1′,2′-oxetane-uridine bearing a 2′-C-methyl substituent, [1-(1′,3′-O-anhydro-3′-C-methyl-β-d-psicofuranosyl)uracil], is described. Key to its construction was the use of 6-O-(p-toluoyl)-1,2:3,4-di-O-isopropylidene-3-C-methyl-d-psicofuranose as a nucleosidation...

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Veröffentlicht in:	Tetrahedron letters 2014-11, Vol.55 (45), p.6216-6219
Hauptverfasser:	Komsta, Zofia, Mayes, Benjamin, Moussa, Adel, Shelbourne, Montserrat, Stewart, Alistair, Tyrrell, Andrew J., Wallis, Laura L., Weymouth-Wilson, Alexander C., Yurek-George, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Bearing Bicyclic ribonucleosides Conformational restriction Construction Guanosines HCV Inhibition Inhibitors Oxetane Polymerase Psicose Synthesis (chemistry) Tetrahedrons
Online-Zugang:	Volltext
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