Synthesis of quinazoline based chiral ligands and application in the enantioselective addition of phenylacetylene to aldehydes

Five novel 4-phenylquinazolinols were synthesised in three steps. Their application as ligands in the titanium tetraisopropoxide promoted catalytic enantioselective addition of phenylacetylene to a variety of aldehydes gave propargylic alcohols. Under the optimised reaction conditions, the best enan...

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Veröffentlicht in:	Tetrahedron 2014-11, Vol.70 (44), p.8385-8388
Hauptverfasser:	Karakaya, Idris, Karabuga, Semistan, Altundas, Ramazan, Ulukanli, Sabri
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Aldehydes Asymmetric alkynylation Catalysis Derivatives Diethylzinc and organozinc addition Ligands Phenylacetylene Propargylic alcohol Quinazolines Quinazolinones Synthesis (chemistry) Tetrahedrons Titanium
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