4-(Dimethylamino)pyridine as a catalyst for the lactonization of 4-hydroxy-2-methylenebutanoate esters

4-(Dimethylamino)pyridine as a catalyst for the lactonization of 4-hydroxy-2-methylenebutanoate esters

The catalytic action of 4-(dimethylamino)pyridine (DMAP) in lactonizing 4-hydroxy-2-methylenebutanoate esters to 2-methylene-γ-butyrolactones is described. The use of DMAP, which functions as an excellent complement to the more traditional acid-catalyzed lactonization protocol, allows for the synthe...

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Veröffentlicht in:Tetrahedron letters 2014-03, Vol.55 (13), p.2075-2077
1. Verfasser: Nicponski, Daniel R.
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Catalysts
Complement
Cyclization
Esterification
Esters
Green chemistry
Lactonization
Synthesis
Tetrahedrons
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Zusammenfassung:The catalytic action of 4-(dimethylamino)pyridine (DMAP) in lactonizing 4-hydroxy-2-methylenebutanoate esters to 2-methylene-γ-butyrolactones is described. The use of DMAP, which functions as an excellent complement to the more traditional acid-catalyzed lactonization protocol, allows for the synthesis of 2-methylene-γ-butyrolactones containing acid-sensitive groups under essentially neutral conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.02.024