l-Proline as an efficicent catalyst for the multi-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-c a rbonitriles in water
An efficient four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-c a rbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes using l-proline (10 mol %) in water under mild reaction condition in excellent yields is est...
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| Veröffentlicht in: | Tetrahedron letters 2011-06, Vol.52 (25), p.3228-3231 |
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| container_title | Tetrahedron letters |
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| creator | Mecadon, Hormi Rohman, MdRumum Kharbangar, Iadeishisha Laloo, Badaker M Kharkongor, Icydora Rajbangshi, Mantu Myrboh, Bekington |
| description | An efficient four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-c a rbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes using l-proline (10 mol %) in water under mild reaction condition in excellent yields is established. A comparative study of l-proline with gamma -alumina, basic alumina, and KF-alumina was also carried out. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated. |
| doi_str_mv | 10.1016/j.tetlet.2011.04.048 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0040-4039 |
| ispartof | Tetrahedron letters, 2011-06, Vol.52 (25), p.3228-3231 |
| issn | 0040-4039 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1744689815 |
| source | Elsevier ScienceDirect Journals |
| subjects | Aldehydes Aluminum oxide Catalysts Hydrates Hydrazines Synthesis (chemistry) Tetrahedrons Tolerances |
| title | l-Proline as an efficicent catalyst for the multi-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-c a rbonitriles in water |
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