Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditions
An expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed by reduction with LiAlH4. Various amides/lactams including hindered amides and secondary amides gave the corresponding amines in good to excellent yi...
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| Veröffentlicht in: | Tetrahedron letters 2013-09, Vol.54 (36), p.4908-4913 |
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| container_title | Tetrahedron letters |
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| creator | Ravinder, B. Rajeswar Reddy, S. Panasa Reddy, A. Bandichhor, Rakeshwar |
| description | An expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed by reduction with LiAlH4. Various amides/lactams including hindered amides and secondary amides gave the corresponding amines in good to excellent yields. This novel protocol has a wide substrate scope and shows good functional group tolerance with high stereoretention. |
| doi_str_mv | 10.1016/j.tetlet.2013.06.144 |
| format | Article |
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| ispartof | Tetrahedron letters, 2013-09, Vol.54 (36), p.4908-4913 |
| issn | 0040-4039 1873-3581 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1744688131 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Activation Amides Amines Functional groups Lithium aluminum hydride Reduction Reductive amination Tetrahedrons Tolerances Trimethylsilyl chloride |
| title | Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditions |
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