Scalable synthesis of (−)-trans-3-hydroxypipecolic acid via a useful chiral building block

Scalable synthesis of (−)-trans-3-hydroxypipecolic acid via a useful chiral building block

A scalable synthesis of (-)-trans-2-(hydroxymethyl)-1,2,3,6-tetrahydropyridin-3-ol, a versatile chiral building block is described along with its transformation to (-)-trans-3-hydroxypipecolic acid.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron 2014-04, Vol.70 (14), p.2444-2448
Hauptverfasser: Karjalainen, Oskari K., Koskinen, Ari M.P.
Format: Artikel
Sprache:eng
Schlagworte:
Synthesis (chemistry)
Tetrahedrons
Transformations
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Beschreibung
Zusammenfassung:A scalable synthesis of (-)-trans-2-(hydroxymethyl)-1,2,3,6-tetrahydropyridin-3-ol, a versatile chiral building block is described along with its transformation to (-)-trans-3-hydroxypipecolic acid.
ISSN:0040-4020
DOI:10.1016/j.tet.2014.02.020