Synthesis of novel steroid analogues containing nitrile and disulfide moieties via palladium-catalyzed cross-coupling reactions

Grundmann's ketone ( 3) was used as a common building block for introduction of the C+D ring motif of steroids to prepare series of novel secosteroids containing nitrile or disulfide functionalities. Key steps in synthesis of these novel steroid analogues are palladium-catalyzed cross-coupling...

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