Atom-economical isocyanide-based multicomponent synthesis of 2,5-dioxopyrrolidines, spirobenzothiazinechromans and 1,5-benzothiazepines

An efficient synthesis of new pharmaceutically relevant dioxopyrrolidines, spirobenzo thiazine-2,3′-chromans, and benzothiazepines via isocyanide-based multicomponent condensation reactions at room temperature is reported. This synthesis serves as a nice addition to group-assistant-purification (GAP...

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Veröffentlicht in:	Tetrahedron 2014-01, Vol.70 (2), p.169-175
Hauptverfasser:	Akbarzadeh, Roya, Amanpour, Tayebeh, Khavasi, Hamid Reza, Bazgir, Ayoob
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzothiazepines Chromatography Dioxopyrrolidine Ethanol Ethyl alcohol Isocyanide Purification Recrystallization Spirobenzothiazine-2,3′-chroman Synthesis Tetrahedrons Washing
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