Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

Orthogonal syntheses of 4-, 5-, 6-, and 7-chloro substituted tryptamine derivatives were performed under the Grandberg–Zuyanova-modified Fisher indole-synthesis conditions. In the 4- and 6-substituted tryptamine cases, a bromine atom was utilized as an easily cleavable protecting group, which allowe...

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Veröffentlicht in:	Tetrahedron letters 2014-01, Vol.55 (4), p.830-833
Hauptverfasser:	René, Olivier, Fauber, Benjamin P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bromine Catalysis Chlorine Derivatives Fisher indole synthesis Handles Late-stage functionalization Protecting group Tetrahedrons Tryptamine Tryptamines
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