Chromatographic separation and spectroscopic characterization of the e/z isomers of acrivastine
A reverse phase high performance liquid chromatography (HPLC) method has been developed for the separation of two geometric isomers of Acrivastine using crude reaction mixture. The resolution between two isomers was found more than 2.9. The geometric isomers have been isolated by preparative HPLC an...
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| Veröffentlicht in: | Chirality (New York, N.Y.) N.Y.), 2011-11, Vol.23 (10), p.955-960 |
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| container_title | Chirality (New York, N.Y.) |
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| creator | Davadra, Prakash M. Dabhi, Batuk Singh, Manoj K. Jain, Mukul R. Joshi, Hitendra S. Bapodra, Atul H. |
| description | A reverse phase high performance liquid chromatography (HPLC) method has been developed for the separation of two geometric isomers of Acrivastine using crude reaction mixture. The resolution between two isomers was found more than 2.9. The geometric isomers have been isolated by preparative HPLC and characterized by spectroscopic techniques, such as NMR, infrared, and MS. The developed method has been validated for the determination of Z‐isomer in Acrivastine. The limit of detection and limit of quantification of the Z‐isomer were 0.05 and 0.2 μg/ml, respectively. The developed method is precise, linear, accurate, rugged and robust for its intended use. Chirality, 2011. © 2011 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/chir.21022 |
| format | Article |
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The resolution between two isomers was found more than 2.9. The geometric isomers have been isolated by preparative HPLC and characterized by spectroscopic techniques, such as NMR, infrared, and MS. The developed method has been validated for the determination of Z‐isomer in Acrivastine. The limit of detection and limit of quantification of the Z‐isomer were 0.05 and 0.2 μg/ml, respectively. The developed method is precise, linear, accurate, rugged and robust for its intended use. Chirality, 2011. © 2011 Wiley‐Liss, Inc.</description><identifier>ISSN: 0899-0042</identifier><identifier>ISSN: 1520-636X</identifier><identifier>EISSN: 1520-636X</identifier><identifier>DOI: 10.1002/chir.21022</identifier><identifier>PMID: 21953883</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acrivastine ; Chirality ; Chromatography ; Chromatography, High Pressure Liquid ; E/Z isomers ; geometric isomers ; High performance liquid chromatography ; HPLC ; Infrared ; Isomers ; Nuclear magnetic resonance ; Reproducibility of Results ; Separation ; Spectroscopy ; Spectrum Analysis ; Stereoisomerism ; Triprolidine - analogs & derivatives ; Triprolidine - chemistry ; Triprolidine - isolation & purification ; validation</subject><ispartof>Chirality (New York, N.Y.), 2011-11, Vol.23 (10), p.955-960</ispartof><rights>Copyright © 2011 Wiley‐Liss, Inc.</rights><rights>Copyright © 2011 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4662-5345c6a9a5406a3a060ee93a81f7175e3920c45c29dd3a61a209e9c49b80c2bb3</citedby><cites>FETCH-LOGICAL-c4662-5345c6a9a5406a3a060ee93a81f7175e3920c45c29dd3a61a209e9c49b80c2bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchir.21022$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchir.21022$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21953883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davadra, Prakash M.</creatorcontrib><creatorcontrib>Dabhi, Batuk</creatorcontrib><creatorcontrib>Singh, Manoj K.</creatorcontrib><creatorcontrib>Jain, Mukul R.</creatorcontrib><creatorcontrib>Joshi, Hitendra S.</creatorcontrib><creatorcontrib>Bapodra, Atul H.</creatorcontrib><title>Chromatographic separation and spectroscopic characterization of the e/z isomers of acrivastine</title><title>Chirality (New York, N.Y.)</title><addtitle>Chirality</addtitle><description>A reverse phase high performance liquid chromatography (HPLC) method has been developed for the separation of two geometric isomers of Acrivastine using crude reaction mixture. The resolution between two isomers was found more than 2.9. The geometric isomers have been isolated by preparative HPLC and characterized by spectroscopic techniques, such as NMR, infrared, and MS. The developed method has been validated for the determination of Z‐isomer in Acrivastine. The limit of detection and limit of quantification of the Z‐isomer were 0.05 and 0.2 μg/ml, respectively. The developed method is precise, linear, accurate, rugged and robust for its intended use. Chirality, 2011. © 2011 Wiley‐Liss, Inc.</description><subject>Acrivastine</subject><subject>Chirality</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>E/Z isomers</subject><subject>geometric isomers</subject><subject>High performance liquid chromatography</subject><subject>HPLC</subject><subject>Infrared</subject><subject>Isomers</subject><subject>Nuclear magnetic resonance</subject><subject>Reproducibility of Results</subject><subject>Separation</subject><subject>Spectroscopy</subject><subject>Spectrum Analysis</subject><subject>Stereoisomerism</subject><subject>Triprolidine - analogs & derivatives</subject><subject>Triprolidine - chemistry</subject><subject>Triprolidine - isolation & purification</subject><subject>validation</subject><issn>0899-0042</issn><issn>1520-636X</issn><issn>1520-636X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PFEEURStEAwOy4QeYXhqThlef3bU0ExkwRIWosKu8qXljl05PtVU9Ivx6e2xgKauXvHvuXRzGjjgccwBx4puQjgUHIXbYhGsBpZHm5gWbQG1tCaDEHtvP-QcAWCPVLtsT3GpZ13LC3LRJscU-fk_YNcEXmTpM2Ie4LnC9KHJHvk8x-9gNoW-GzPeUwv2IxGXRN1TQyX0Rcmwp5e0LfQq_MfdhTa_YyyWuMh0-3AP29fT9l-lZefFpdj59d1F6ZYwotVTaG7SoFRiUCAaIrMSaLyteaZJWgB8QYRcLiYajAEvWKzuvwYv5XB6wN-Nul-KvDeXetSF7Wq1wTXGTHa-UMrXWVjyPGjFY1ULbAX07on5QkBMtXZdCi-nOcXBb927r3v1zP8CvH3Y385YWT-ij7AHgI3AbVnT3nyk3PTu_ehwtx07IPf156mD66UwlK-2uP86cujydfbj8XLlv8i8I6J5s</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>Davadra, Prakash M.</creator><creator>Dabhi, Batuk</creator><creator>Singh, Manoj K.</creator><creator>Jain, Mukul R.</creator><creator>Joshi, Hitendra S.</creator><creator>Bapodra, Atul H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>201111</creationdate><title>Chromatographic separation and spectroscopic characterization of the e/z isomers of acrivastine</title><author>Davadra, Prakash M. ; Dabhi, Batuk ; Singh, Manoj K. ; Jain, Mukul R. ; Joshi, Hitendra S. ; Bapodra, Atul H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4662-5345c6a9a5406a3a060ee93a81f7175e3920c45c29dd3a61a209e9c49b80c2bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acrivastine</topic><topic>Chirality</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>E/Z isomers</topic><topic>geometric isomers</topic><topic>High performance liquid chromatography</topic><topic>HPLC</topic><topic>Infrared</topic><topic>Isomers</topic><topic>Nuclear magnetic resonance</topic><topic>Reproducibility of Results</topic><topic>Separation</topic><topic>Spectroscopy</topic><topic>Spectrum Analysis</topic><topic>Stereoisomerism</topic><topic>Triprolidine - analogs & derivatives</topic><topic>Triprolidine - chemistry</topic><topic>Triprolidine - isolation & purification</topic><topic>validation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davadra, Prakash M.</creatorcontrib><creatorcontrib>Dabhi, Batuk</creatorcontrib><creatorcontrib>Singh, Manoj K.</creatorcontrib><creatorcontrib>Jain, Mukul R.</creatorcontrib><creatorcontrib>Joshi, Hitendra S.</creatorcontrib><creatorcontrib>Bapodra, Atul H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chirality (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davadra, Prakash M.</au><au>Dabhi, Batuk</au><au>Singh, Manoj K.</au><au>Jain, Mukul R.</au><au>Joshi, Hitendra S.</au><au>Bapodra, Atul H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromatographic separation and spectroscopic characterization of the e/z isomers of acrivastine</atitle><jtitle>Chirality (New York, N.Y.)</jtitle><addtitle>Chirality</addtitle><date>2011-11</date><risdate>2011</risdate><volume>23</volume><issue>10</issue><spage>955</spage><epage>960</epage><pages>955-960</pages><issn>0899-0042</issn><issn>1520-636X</issn><eissn>1520-636X</eissn><abstract>A reverse phase high performance liquid chromatography (HPLC) method has been developed for the separation of two geometric isomers of Acrivastine using crude reaction mixture. The resolution between two isomers was found more than 2.9. The geometric isomers have been isolated by preparative HPLC and characterized by spectroscopic techniques, such as NMR, infrared, and MS. The developed method has been validated for the determination of Z‐isomer in Acrivastine. The limit of detection and limit of quantification of the Z‐isomer were 0.05 and 0.2 μg/ml, respectively. The developed method is precise, linear, accurate, rugged and robust for its intended use. Chirality, 2011. © 2011 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21953883</pmid><doi>10.1002/chir.21022</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acrivastine Chirality Chromatography Chromatography, High Pressure Liquid E/Z isomers geometric isomers High performance liquid chromatography HPLC Infrared Isomers Nuclear magnetic resonance Reproducibility of Results Separation Spectroscopy Spectrum Analysis Stereoisomerism Triprolidine - analogs & derivatives Triprolidine - chemistry Triprolidine - isolation & purification validation |
| title | Chromatographic separation and spectroscopic characterization of the e/z isomers of acrivastine |
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