A synthesis of dihydroimidazo[5,1- a]isoquinolines using a sequential Ugi–Bischler–Napieralski reaction sequence

A flexible route to analogues of dihydroimidazo[5,1- a]isoquinolines is described. The synthesis hinges on a sequential Ugi coupling, followed by a Bischler–Napieralski reaction to form the imidazole isoquinoline core. This route facilitates the introduction of a range of substitutions throughout th...

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Veröffentlicht in:	Tetrahedron letters 2012-02, Vol.53 (8), p.903-905
Hauptverfasser:	Seganish, W. Michael, Bercovici, Ana, Ho, Ginny D., Loozen, Hubert J.J., Timmers, Cornelis M., Tulshian, Deen
Format:	Artikel
Sprache:	eng
Schlagworte:	Bischler–Napieralski Carbon Hinges Imidazole Isoquinoline Joining Synthesis (chemistry) Tetrahedrons Ugi coupling
Online-Zugang:	Volltext
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