NannocystinA: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties

Cultivation of myxobacteria of the Nannocystis genus led to the isolation and structure elucidation of a class of novel cyclic lactone inhibitors of elongation factor1. Whole genome sequence analysis and annotation enabled identification of the putative biosynthetic cluster and synthesis process. In...

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Veröffentlicht in:	Angewandte Chemie 2015-08, Vol.127 (35), p.10287-10292
Hauptverfasser:	Krastel, Philipp, Roggo, Silvio, Schirle, Markus, Ross, Nathan T, Perruccio, Francesca, Aspesi, Peter, Aust, Thomas, Buntin, Kathrin, Estoppey, David, Liechty, Brigitta, Mapa, Felipa, Memmert, Klaus, Miller, Howard, Pan, Xuewen, Riedl, Ralph, Thibaut, Christian, Thomas, Jason, Wagner, Trixie, Weber, Eric, Xie, Xiaobing, Schmitt, Esther K, Hoepfner, Dominic
Format:	Artikel
Sprache:	eng ; ger
Schlagworte:	Binding sites Biological Cancer Chemistry Clusters Elongation Genetics Inhibitors Synthesis
Online-Zugang:	Volltext
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