Useful four-carbon synthons en route to monastrol analogs
A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI...
Gespeichert in:
| Veröffentlicht in: | Tetrahedron 2015-01, Vol.71 (1), p.139-146 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 146 |
|---|---|
| container_issue | 1 |
| container_start_page | 139 |
| container_title | Tetrahedron |
| container_volume | 71 |
| creator | Abdou, Amr M. Botros, S. Hassan, Rasha A. Kamel, Mona M. Taber, Douglass F. Taher, Azza T. |
| description | A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI 60 cell line panel.
[Display omitted] |
| doi_str_mv | 10.1016/j.tet.2014.11.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1744682526</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0040402014015804</els_id><sourcerecordid>1744682526</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-10f59e0cf44071490f84121d150bb1e322b69758713ecffe7330d4d39f50db923</originalsourceid><addsrcrecordid>eNp9kD1PwzAURS0EEqHwA9gysiS8ZztOIyZU8SVVYqGzlTjPkCq1i-0g9d-TqsxMd7nnSvcwdotQIqC635aJUskBZYlYAudnLEOpZFFJVOcsA5BQSOBwya5i3AIAIhcZazaR7DTm1k-hMG3ovMvjwaUv72JOLg9-SpQnn--8a2MKfsxb147-M16zC9uOkW7-csE2z08fq9di_f7ytnpcF0Y0KhUItmoIjJUSapQN2KVEjj1W0HVIgvNONXW1rFGQsZZqIaCXvWhsBX3XcLFgd6fdffDfE8Wkd0M0NI6tIz9FjbWUaskrruYqnqom-BgDWb0Pw64NB42gj5r0Vs-a9FGTRtSzppl5ODE0f_gZKOhoBnKG-iGQSbr3wz_0Lzv9bug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1744682526</pqid></control><display><type>article</type><title>Useful four-carbon synthons en route to monastrol analogs</title><source>Access via ScienceDirect (Elsevier)</source><creator>Abdou, Amr M. ; Botros, S. ; Hassan, Rasha A. ; Kamel, Mona M. ; Taber, Douglass F. ; Taher, Azza T.</creator><creatorcontrib>Abdou, Amr M. ; Botros, S. ; Hassan, Rasha A. ; Kamel, Mona M. ; Taber, Douglass F. ; Taher, Azza T.</creatorcontrib><description>A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI 60 cell line panel.
[Display omitted]</description><identifier>ISSN: 0040-4020</identifier><identifier>EISSN: 1464-5416</identifier><identifier>DOI: 10.1016/j.tet.2014.11.022</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Analogs ; Anti-cancer activity ; Anticancer properties ; Biginelli ; Biotechnology ; Crystal structure ; Ester exchange ; Esters ; Monastrol analogs ; Panels ; Tetrahedrons</subject><ispartof>Tetrahedron, 2015-01, Vol.71 (1), p.139-146</ispartof><rights>2014 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-10f59e0cf44071490f84121d150bb1e322b69758713ecffe7330d4d39f50db923</citedby><cites>FETCH-LOGICAL-c396t-10f59e0cf44071490f84121d150bb1e322b69758713ecffe7330d4d39f50db923</cites><orcidid>0000-0001-8149-5882</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tet.2014.11.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids></links><search><creatorcontrib>Abdou, Amr M.</creatorcontrib><creatorcontrib>Botros, S.</creatorcontrib><creatorcontrib>Hassan, Rasha A.</creatorcontrib><creatorcontrib>Kamel, Mona M.</creatorcontrib><creatorcontrib>Taber, Douglass F.</creatorcontrib><creatorcontrib>Taher, Azza T.</creatorcontrib><title>Useful four-carbon synthons en route to monastrol analogs</title><title>Tetrahedron</title><description>A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI 60 cell line panel.
[Display omitted]</description><subject>Analogs</subject><subject>Anti-cancer activity</subject><subject>Anticancer properties</subject><subject>Biginelli</subject><subject>Biotechnology</subject><subject>Crystal structure</subject><subject>Ester exchange</subject><subject>Esters</subject><subject>Monastrol analogs</subject><subject>Panels</subject><subject>Tetrahedrons</subject><issn>0040-4020</issn><issn>1464-5416</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAURS0EEqHwA9gysiS8ZztOIyZU8SVVYqGzlTjPkCq1i-0g9d-TqsxMd7nnSvcwdotQIqC635aJUskBZYlYAudnLEOpZFFJVOcsA5BQSOBwya5i3AIAIhcZazaR7DTm1k-hMG3ovMvjwaUv72JOLg9-SpQnn--8a2MKfsxb147-M16zC9uOkW7-csE2z08fq9di_f7ytnpcF0Y0KhUItmoIjJUSapQN2KVEjj1W0HVIgvNONXW1rFGQsZZqIaCXvWhsBX3XcLFgd6fdffDfE8Wkd0M0NI6tIz9FjbWUaskrruYqnqom-BgDWb0Pw64NB42gj5r0Vs-a9FGTRtSzppl5ODE0f_gZKOhoBnKG-iGQSbr3wz_0Lzv9bug</recordid><startdate>20150107</startdate><enddate>20150107</enddate><creator>Abdou, Amr M.</creator><creator>Botros, S.</creator><creator>Hassan, Rasha A.</creator><creator>Kamel, Mona M.</creator><creator>Taber, Douglass F.</creator><creator>Taher, Azza T.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-8149-5882</orcidid></search><sort><creationdate>20150107</creationdate><title>Useful four-carbon synthons en route to monastrol analogs</title><author>Abdou, Amr M. ; Botros, S. ; Hassan, Rasha A. ; Kamel, Mona M. ; Taber, Douglass F. ; Taher, Azza T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-10f59e0cf44071490f84121d150bb1e322b69758713ecffe7330d4d39f50db923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analogs</topic><topic>Anti-cancer activity</topic><topic>Anticancer properties</topic><topic>Biginelli</topic><topic>Biotechnology</topic><topic>Crystal structure</topic><topic>Ester exchange</topic><topic>Esters</topic><topic>Monastrol analogs</topic><topic>Panels</topic><topic>Tetrahedrons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdou, Amr M.</creatorcontrib><creatorcontrib>Botros, S.</creatorcontrib><creatorcontrib>Hassan, Rasha A.</creatorcontrib><creatorcontrib>Kamel, Mona M.</creatorcontrib><creatorcontrib>Taber, Douglass F.</creatorcontrib><creatorcontrib>Taher, Azza T.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Tetrahedron</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdou, Amr M.</au><au>Botros, S.</au><au>Hassan, Rasha A.</au><au>Kamel, Mona M.</au><au>Taber, Douglass F.</au><au>Taher, Azza T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Useful four-carbon synthons en route to monastrol analogs</atitle><jtitle>Tetrahedron</jtitle><date>2015-01-07</date><risdate>2015</risdate><volume>71</volume><issue>1</issue><spage>139</spage><epage>146</epage><pages>139-146</pages><issn>0040-4020</issn><eissn>1464-5416</eissn><abstract>A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI 60 cell line panel.
[Display omitted]</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.tet.2014.11.022</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8149-5882</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0040-4020 |
| ispartof | Tetrahedron, 2015-01, Vol.71 (1), p.139-146 |
| issn | 0040-4020 1464-5416 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1744682526 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Analogs Anti-cancer activity Anticancer properties Biginelli Biotechnology Crystal structure Ester exchange Esters Monastrol analogs Panels Tetrahedrons |
| title | Useful four-carbon synthons en route to monastrol analogs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T14%3A48%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Useful%20four-carbon%20synthons%20en%20route%20to%20monastrol%20analogs&rft.jtitle=Tetrahedron&rft.au=Abdou,%20Amr%20M.&rft.date=2015-01-07&rft.volume=71&rft.issue=1&rft.spage=139&rft.epage=146&rft.pages=139-146&rft.issn=0040-4020&rft.eissn=1464-5416&rft_id=info:doi/10.1016/j.tet.2014.11.022&rft_dat=%3Cproquest_cross%3E1744682526%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1744682526&rft_id=info:pmid/&rft_els_id=S0040402014015804&rfr_iscdi=true |