Formal synthesis of fumonisin B1, a potent sphingolipid biosynthesis inhibitor

Formal synthesis of fumonisin B1, a potent sphingolipid biosynthesis inhibitor

The formal total synthesis of the important toxin fumonisin B1 is achieved from simple raw materials in a convergent manner. The key functionalities are derived from MacMillan α-hydroxylation, sharpless asymmetric dihydroxylation and ring-closing metathesis.

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Veröffentlicht in:Tetrahedron letters 2012-06, Vol.53 (26), p.3233-3236
Hauptverfasser: Chandrasekhar, Srivari, Sreelakshmi, Lella
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
Biosynthesis
d-Mannitol
Fumonisin B1
Inhibitors
MacMillan α-hydroxylation
Metathesis
Raw materials
Ring-closing metathesis
Sphingolipid
Synthesis (chemistry)
Tetrahedrons
Toxins
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Zusammenfassung:The formal total synthesis of the important toxin fumonisin B1 is achieved from simple raw materials in a convergent manner. The key functionalities are derived from MacMillan α-hydroxylation, sharpless asymmetric dihydroxylation and ring-closing metathesis.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.04.030