An efficient green protocol for the synthesis of coumarin fused highly decorated indenodihydropyridyl and dihydropyridyl derivatives

A simple, convenient, environmentally benign, and mild synthetic method has been established to afford highly decorated indenodihydropyridine and dihydropyridine derivatives employing a green solvent ethyl-l-lactate and an organo-catalyst (±)lactic acid. A wide range of functional groups were tolera...

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Veröffentlicht in:Tetrahedron letters 2012-04, Vol.53 (17), p.2206-2210
Hauptverfasser: Paul, Sanjay, Das, Asish R.
Format: Artikel
Sprache:eng
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Zusammenfassung:A simple, convenient, environmentally benign, and mild synthetic method has been established to afford highly decorated indenodihydropyridine and dihydropyridine derivatives employing a green solvent ethyl-l-lactate and an organo-catalyst (±)lactic acid. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in moderate to good yields applying the current method.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.02.077