A novel oxidative decarboxylation—synthesis of 2-amino-1,2-dihydroisoquinoline-3(4 H)-one and its amide derivatives from tetrahydroisoquinoline-3-carboxylic acid

A convenient method of synthesizing 2-amino-1,2-dihydroisoquinoline-3(4 H)-one and its amide derivatives ( 4 or 5) is described through sydnone intermediate ( 3) derived from TIC ( 1) (tetrahydroisoquinoline-3-carboxylic acid) under acidic conditions in good yield.

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Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2011-10, Vol.52 (42), p.5441-5443
Hauptverfasser:	Gopalan, B., Umamaheswari, Mani, Mohan, P.S., Rajagopal, Sridharan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Chemistry Derivatives Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Organic chemistry Preparations and properties Tetrahedrons
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Beschreibung
Zusammenfassung:	A convenient method of synthesizing 2-amino-1,2-dihydroisoquinoline-3(4 H)-one and its amide derivatives ( 4 or 5) is described through sydnone intermediate ( 3) derived from TIC ( 1) (tetrahydroisoquinoline-3-carboxylic acid) under acidic conditions in good yield.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.08.007