Expedient one-step synthesis of nitrogen stilbene analogs by transition metal-free hydroamination of arylacetylenes with pyrroles

A novel family of nitrogen stilbene analogs, 1-styrylpyrroles, has been synthesized in good to excellent yields by a straightforward facile transition metal-free addition of pyrroles to arylacetylenes in the KOH/DMSO system (90–120°C, 5–13h). Thermodynamically controlled E/Z-isomer ratio of 1-styryl...

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Veröffentlicht in:	Tetrahedron 2012-02, Vol.68 (7), p.1963-1971
Hauptverfasser:	Dvorko, Marina Yu, Schmidt, Elena Yu, Glotova, Tatyana E., Shabalin, Dmitrii A., Ushakov, Igor' A., Kobychev, Vladimir B., Petrushenko, Konstantin B., Mikhaleva, Al'bina I., Trofimov, Boris A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Isomerization Nucleophilic addition Pyrroles Stilbene Styrylpyrroles Superbase Synthesis (chemistry) Tetrahedrons
Online-Zugang:	Volltext
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