Auxiliary-directed oxidation of ursolic acid by ‘Ru’-porphyrins: chemical modulation of cytotoxicity against tumor cell lines

Derivatization of ursolic acid, one of the natural ursene-type pentacyclic triterpenes, was investigated by the oxidation with dioxoruthenium(VI) tetraphenylporphyrins. Oxidation selectivity on the terpene structure was modulated by the auxiliaries introduced on the tetraphenylporphyrin. Chemical ox...

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Veröffentlicht in:	Tetrahedron letters 2012-04, Vol.53 (14), p.1756-1759
Hauptverfasser:	Tanaka, Katsunori, Mazumder, Kishor, Siwu, Eric R.O., Nozaki, Satoshi, Watanabe, Yasuyoshi, Fukase, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomimetic oxidation Biotechnology Cytochrome P450 Cytotoxicity Dioxoruthenium(VI) tetraphenylporphyrin Modulation Oxidation Selectivity Terpenes Tetrahedrons Tumors Ursolic acid
Online-Zugang:	Volltext
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