Synthesis of 3-(1H-benzo[d]imidazol-1-yl)isoindolin-1-one derivatives promoted by EtOHaAcOH solvent system

Synthesis of 3-(1H-benzo[d]imidazol-1-yl)isoindolin-1-one derivatives promoted by EtOHaAcOH solvent system

A simple and efficient method for the synthesis of 3-(1H-benzo[d]imidazol-1-yl)isoindolin-1-one derivatives by a one-pot, three-component condensation reaction of phthalaldehydic acid, primary amine, and 2-mercaptobenzimidazole or 2-hydroxybenzimidazole is described. By using EtOHaAcOH (v/v, 15:1) a...

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Veröffentlicht in:Tetrahedron letters 2013-06, Vol.54 (23), p.2972-2975
Hauptverfasser: You, Hanyun, Chen, Fanglei, Lei, Min, Hu, Lihong
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Condensates
Derivatives
Solvents
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:A simple and efficient method for the synthesis of 3-(1H-benzo[d]imidazol-1-yl)isoindolin-1-one derivatives by a one-pot, three-component condensation reaction of phthalaldehydic acid, primary amine, and 2-mercaptobenzimidazole or 2-hydroxybenzimidazole is described. By using EtOHaAcOH (v/v, 15:1) as the solvent system, the reaction proceeds smoothly to give corresponding products in good yields.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2013.03.126