Creating Space for Large Acceptors: Rational Biocatalyst Design for Resveratrol Glycosylation in an Aqueous System

Polyphenols display a number of interesting properties but their low solubility limits practical applications. In that respect, glycosylation offers a solution for which sucrose phosphorylase has been proposed as a cost‐effective biocatalyst. However, its activity on alternative acceptor substrates...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-08, Vol.54 (32), p.9289-9292
Hauptverfasser:	Dirks-Hofmeister, Mareike E., Verhaeghe, Tom, De Winter, Karel, Desmet, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Binding Sites Biocatalysis Biocatalysts Catalytic Domain Design engineering Docking Enzymes - chemistry Enzymes - genetics Enzymes - metabolism Glucosyltransferases - chemistry Glucosyltransferases - genetics Glucosyltransferases - metabolism Glycosylation Kinetics Mathematical models Molecular Docking Simulation Mutagenesis, Site-Directed Phosphorylases Polyphenols protein engineering resveratrol Solubility Stilbenes - chemistry Stilbenes - metabolism Substrate Specificity Sucrose sucrose phosphorylase Thermoanaerobacterium - enzymology Water - chemistry
Online-Zugang:	Volltext
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