Mussel-Inspired Protein Nanoparticles Containing Iron(III)-DOPA Complexes for pH-Responsive Drug Delivery
A novel bioinspired strategy for protein nanoparticle (NP) synthesis to achieve pH‐responsive drug release exploits the pH‐dependent changes in the coordination stoichiometry of iron(III)–3,4‐dihydroxyphenylalanine (DOPA) complexes, which play a major cross‐linking role in mussel byssal threads. Dox...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2015-06, Vol.54 (25), p.7318-7322 |
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| creator | Kim, Bum Jin Cheong, Hogyun Hwang, Byeong Hee Cha, Hyung Joon |
| description | A novel bioinspired strategy for protein nanoparticle (NP) synthesis to achieve pH‐responsive drug release exploits the pH‐dependent changes in the coordination stoichiometry of iron(III)–3,4‐dihydroxyphenylalanine (DOPA) complexes, which play a major cross‐linking role in mussel byssal threads. Doxorubicin‐loaded polymeric NPs that are based on FeIII–DOPA complexation were thus synthesized with a DOPA‐modified recombinant mussel adhesive protein through a co‐electrospraying process. The release of doxorubicin was found to be predominantly governed by a change in the structure of the FeIII–DOPA complexes induced by an acidic pH value. It was also demonstrated that the fabricated NPs exhibited effective cytotoxicity towards cancer cells through efficient cellular uptake and cytosolic release. Therefore, it is anticipated that FeIII–DOPA complexation can be successfully utilized as a new design principle for pH‐responsive NPs for diverse controlled drug‐delivery applications.
Mussel‐inspired protein nanoparticles that are capable of pH‐responsive drug release were obtained by exploiting the pH‐dependent changes in the stoichiometry of iron(III)–DOPA complexes. Such doxorubicin‐loaded polymeric nanoparticles were synthesized through a co‐electrospraying process and shown to release doxorubicin at acidic pH values. DOPA=3,4‐dihydroxyphenylalanine. |
| doi_str_mv | 10.1002/anie.201501748 |
| format | Article |
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Mussel‐inspired protein nanoparticles that are capable of pH‐responsive drug release were obtained by exploiting the pH‐dependent changes in the stoichiometry of iron(III)–DOPA complexes. Such doxorubicin‐loaded polymeric nanoparticles were synthesized through a co‐electrospraying process and shown to release doxorubicin at acidic pH values. DOPA=3,4‐dihydroxyphenylalanine.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201501748</identifier><identifier>PMID: 25968933</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; Antibiotics, Antineoplastic - administration & dosage ; Antibiotics, Antineoplastic - pharmacology ; Bivalvia - chemistry ; Complexation ; Delayed-Action Preparations - chemistry ; Dihydroxyphenylalanine - chemistry ; Doxorubicin ; Doxorubicin - administration & dosage ; Doxorubicin - pharmacology ; drug delivery ; Drug Delivery Systems ; electrospray ; Ferric Compounds - chemistry ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; iron complexes ; Mussels ; Nanoparticles ; Nanoparticles - chemistry ; Neoplasms - drug therapy ; Proteins ; Proteins - chemistry ; Stoichiometry ; Strategy</subject><ispartof>Angewandte Chemie International Edition, 2015-06, Vol.54 (25), p.7318-7322</ispartof><rights>2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6178-a10df65fd1e56676432eb6a3464ea6c406f712d69ad79e4b773bfa0222b515cd3</citedby><cites>FETCH-LOGICAL-c6178-a10df65fd1e56676432eb6a3464ea6c406f712d69ad79e4b773bfa0222b515cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201501748$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201501748$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25968933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Bum Jin</creatorcontrib><creatorcontrib>Cheong, Hogyun</creatorcontrib><creatorcontrib>Hwang, Byeong Hee</creatorcontrib><creatorcontrib>Cha, Hyung Joon</creatorcontrib><title>Mussel-Inspired Protein Nanoparticles Containing Iron(III)-DOPA Complexes for pH-Responsive Drug Delivery</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>A novel bioinspired strategy for protein nanoparticle (NP) synthesis to achieve pH‐responsive drug release exploits the pH‐dependent changes in the coordination stoichiometry of iron(III)–3,4‐dihydroxyphenylalanine (DOPA) complexes, which play a major cross‐linking role in mussel byssal threads. Doxorubicin‐loaded polymeric NPs that are based on FeIII–DOPA complexation were thus synthesized with a DOPA‐modified recombinant mussel adhesive protein through a co‐electrospraying process. The release of doxorubicin was found to be predominantly governed by a change in the structure of the FeIII–DOPA complexes induced by an acidic pH value. It was also demonstrated that the fabricated NPs exhibited effective cytotoxicity towards cancer cells through efficient cellular uptake and cytosolic release. Therefore, it is anticipated that FeIII–DOPA complexation can be successfully utilized as a new design principle for pH‐responsive NPs for diverse controlled drug‐delivery applications.
Mussel‐inspired protein nanoparticles that are capable of pH‐responsive drug release were obtained by exploiting the pH‐dependent changes in the stoichiometry of iron(III)–DOPA complexes. Such doxorubicin‐loaded polymeric nanoparticles were synthesized through a co‐electrospraying process and shown to release doxorubicin at acidic pH values. DOPA=3,4‐dihydroxyphenylalanine.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Bivalvia - chemistry</subject><subject>Complexation</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Dihydroxyphenylalanine - chemistry</subject><subject>Doxorubicin</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - pharmacology</subject><subject>drug delivery</subject><subject>Drug Delivery Systems</subject><subject>electrospray</subject><subject>Ferric Compounds - chemistry</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>iron complexes</subject><subject>Mussels</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - drug therapy</subject><subject>Proteins</subject><subject>Proteins - chemistry</subject><subject>Stoichiometry</subject><subject>Strategy</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EoqVw5YgicSkHL_6KnRxXu6UbqaQFQTlaTjKpXLJ2aifQ_e9xtWWFuPTkkfx7T_PmIfSWkgUlhH00zsKCEZoTqkTxDB3TnFHMleLP0yw4x6rI6RF6FeNt4ouCyJfoiOWlLErOj5H9PMcIA65cHG2ALrsKfgLrsto4P5ow2XaAmK28m4x11t1kVfDutKqqD3h9ebVMP9txgPvE9D5k4wZ_hTh6F-0vyNZhvsnWMKQ57F6jF70ZIrx5fE_Q909n31YbfHF5Xq2WF7iVVBXYUNL1Mu87CrmUSgrOoJGGCynAyFYQ2SvKOlmaTpUgmpS06Q1hjDU5zduOn6DTve8Y_N0McdJbG1sYBuPAz1GnOwmpUn76NCpLIkVJKEvo-__QWz8Hl4IkqigLlhZViVrsqTb4GAP0egx2a8JOU6If-tIPfelDX0nw7tF2brbQHfC_BSWg3AO_7QC7J-z0sq7O_jXHe62NE9wftCb81FJxlesf9bnefKmvr9erWgv-B_unr5c</recordid><startdate>20150615</startdate><enddate>20150615</enddate><creator>Kim, Bum Jin</creator><creator>Cheong, Hogyun</creator><creator>Hwang, Byeong Hee</creator><creator>Cha, Hyung Joon</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20150615</creationdate><title>Mussel-Inspired Protein Nanoparticles Containing Iron(III)-DOPA Complexes for pH-Responsive Drug Delivery</title><author>Kim, Bum Jin ; Cheong, Hogyun ; Hwang, Byeong Hee ; Cha, Hyung Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6178-a10df65fd1e56676432eb6a3464ea6c406f712d69ad79e4b773bfa0222b515cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Bivalvia - chemistry</topic><topic>Complexation</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Dihydroxyphenylalanine - chemistry</topic><topic>Doxorubicin</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - pharmacology</topic><topic>drug delivery</topic><topic>Drug Delivery Systems</topic><topic>electrospray</topic><topic>Ferric Compounds - chemistry</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>iron complexes</topic><topic>Mussels</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - drug therapy</topic><topic>Proteins</topic><topic>Proteins - chemistry</topic><topic>Stoichiometry</topic><topic>Strategy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Bum Jin</creatorcontrib><creatorcontrib>Cheong, Hogyun</creatorcontrib><creatorcontrib>Hwang, Byeong Hee</creatorcontrib><creatorcontrib>Cha, Hyung Joon</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Bum Jin</au><au>Cheong, Hogyun</au><au>Hwang, Byeong Hee</au><au>Cha, Hyung Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mussel-Inspired Protein Nanoparticles Containing Iron(III)-DOPA Complexes for pH-Responsive Drug Delivery</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2015-06-15</date><risdate>2015</risdate><volume>54</volume><issue>25</issue><spage>7318</spage><epage>7322</epage><pages>7318-7322</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>A novel bioinspired strategy for protein nanoparticle (NP) synthesis to achieve pH‐responsive drug release exploits the pH‐dependent changes in the coordination stoichiometry of iron(III)–3,4‐dihydroxyphenylalanine (DOPA) complexes, which play a major cross‐linking role in mussel byssal threads. Doxorubicin‐loaded polymeric NPs that are based on FeIII–DOPA complexation were thus synthesized with a DOPA‐modified recombinant mussel adhesive protein through a co‐electrospraying process. The release of doxorubicin was found to be predominantly governed by a change in the structure of the FeIII–DOPA complexes induced by an acidic pH value. It was also demonstrated that the fabricated NPs exhibited effective cytotoxicity towards cancer cells through efficient cellular uptake and cytosolic release. Therefore, it is anticipated that FeIII–DOPA complexation can be successfully utilized as a new design principle for pH‐responsive NPs for diverse controlled drug‐delivery applications.
Mussel‐inspired protein nanoparticles that are capable of pH‐responsive drug release were obtained by exploiting the pH‐dependent changes in the stoichiometry of iron(III)–DOPA complexes. Such doxorubicin‐loaded polymeric nanoparticles were synthesized through a co‐electrospraying process and shown to release doxorubicin at acidic pH values. DOPA=3,4‐dihydroxyphenylalanine.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>25968933</pmid><doi>10.1002/anie.201501748</doi><tpages>5</tpages><edition>International ed. in English</edition></addata></record> |
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| subjects | Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacology Bivalvia - chemistry Complexation Delayed-Action Preparations - chemistry Dihydroxyphenylalanine - chemistry Doxorubicin Doxorubicin - administration & dosage Doxorubicin - pharmacology drug delivery Drug Delivery Systems electrospray Ferric Compounds - chemistry HeLa Cells Humans Hydrogen-Ion Concentration iron complexes Mussels Nanoparticles Nanoparticles - chemistry Neoplasms - drug therapy Proteins Proteins - chemistry Stoichiometry Strategy |
| title | Mussel-Inspired Protein Nanoparticles Containing Iron(III)-DOPA Complexes for pH-Responsive Drug Delivery |
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