An efficient one-pot two-step three-component process for the synthesis of perfluoroalkylated biphenyls

An efficient one-pot two-step three-component process for the synthesis of perfluoroalkylated biphenyls

A practical and economical process for the synthesis of perfluoroalkylated biphenyl derivatives has been developed. The three-component reaction of aromatic ketones, malononitrile and methyl perfluoroalk-2-ynoates gave the desired products in good to excellent yields via a one-pot two-step process....

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Veröffentlicht in:Tetrahedron 2015-02, Vol.71 (5), p.820-825
Hauptverfasser: Xu, Yuhong, Han, Jing, Lv, You, Pan, Renming, Chen, Jie, Deng, Hongmei, Shao, Min, Zhang, Hui, Cao, Weiguo
Format: Artikel
Sprache:eng
Schlagworte:
Biphenyl
Derivatives
Economics
Ketones
Malononitrile
MCR
One-pot reaction
Perfluoroalkylated
Synthesis (chemistry)
Tetrahedrons
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Beschreibung
Zusammenfassung:A practical and economical process for the synthesis of perfluoroalkylated biphenyl derivatives has been developed. The three-component reaction of aromatic ketones, malononitrile and methyl perfluoroalk-2-ynoates gave the desired products in good to excellent yields via a one-pot two-step process. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.12.051