DNA-Encoded Dynamic Combinatorial Chemical Libraries

Dynamic combinatorial chemistry (DCC) explores the thermodynamic equilibrium of reversible reactions. Its application in the discovery of protein binders is largely limited by difficulties in the analysis of complex reaction mixtures. DNA‐encoded chemical library (DECL) technology allows the selecti...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-06, Vol.54 (27), p.7924-7928
Hauptverfasser:	Reddavide, Francesco V., Lin, Weilin, Lehnert, Sarah, Zhang, Yixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Binders Biotin - analogs & derivatives Biotin - isolation & purification Biotin - metabolism Combinatorial analysis Combinatorial chemistry Combinatorial Chemistry Techniques Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA-encoded chemical libraries DNA-templated reactions Drug Discovery dynamic combinatorial chemistry Dynamics Enrichment Gene Library Libraries Ligands Protein Binding protein-ligand interactions Proteins Proteins - metabolism Small Molecule Libraries - chemistry Small Molecule Libraries - isolation & purification Small Molecule Libraries - metabolism Streptavidin - metabolism Thermodynamic equilibrium Thermodynamics
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