Oxidation of thiols promoted by PhSeZnCl

Oxidation of thiols promoted by PhSeZnCl

The ability of PhSeZnCl 1 to catalyze the oxidation of thiols to disulfides has been evaluated and correlated to a catalytic GPx-like activity. The first evidence that vinyl phenylselenides can promote the oxidation of thiols reducing hydrogen peroxide through the formation of a selenoxide intermedi...

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Veröffentlicht in:Tetrahedron letters 2012-01, Vol.53 (2), p.232-234
Hauptverfasser: Tidei, Caterina, Piroddi, Marta, Galli, Francesco, Santi, Claudio
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Correlation
Disulfides
Formations
GPx mimetics
Hydrogen peroxide
Oxidation
Peroxide
Selenolate
Tetrahedrons
Thiols
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Zusammenfassung:The ability of PhSeZnCl 1 to catalyze the oxidation of thiols to disulfides has been evaluated and correlated to a catalytic GPx-like activity. The first evidence that vinyl phenylselenides can promote the oxidation of thiols reducing hydrogen peroxide through the formation of a selenoxide intermediate is also reported.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.11.025