Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids
The Ru-catalyzed asymmetric hydrogenation of 2-oxo-4-arybutanoic acids to afford 2-hydroxy-4-arybutanoic acids was accomplished by employing SunPhos as chiral ligand and 1 M aq HBr as additive. The high enantioselectivities (88.4%–92.6% ee) and efficiency (TON=10,000, TOF=300 h −1) make this method...
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| Veröffentlicht in: | Tetrahedron 2011-08, Vol.67 (34), p.6186-6190 |
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| container_issue | 34 |
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| container_title | Tetrahedron |
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| creator | Zhu, Lufeng Chen, Houhe Meng, Qinghua Fan, Weizheng Xie, Xiaomin Zhang, Zhaoguo |
| description | The Ru-catalyzed asymmetric hydrogenation of 2-oxo-4-arybutanoic acids to afford 2-hydroxy-4-arybutanoic acids was accomplished by employing SunPhos as chiral ligand and 1 M aq HBr as additive. The high enantioselectivities (88.4%–92.6% ee) and efficiency (TON=10,000, TOF=300 h
−1) make this method efficient for the synthesis of an important intermediate, (
R)-2-hydroxy-4-phenylbutanoic acid, for ACE inhibitors.
[Display omitted] |
| doi_str_mv | 10.1016/j.tet.2011.06.071 |
| format | Article |
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−1) make this method efficient for the synthesis of an important intermediate, (
R)-2-hydroxy-4-phenylbutanoic acid, for ACE inhibitors.
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−1) make this method efficient for the synthesis of an important intermediate, (
R)-2-hydroxy-4-phenylbutanoic acid, for ACE inhibitors.
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−1) make this method efficient for the synthesis of an important intermediate, (
R)-2-hydroxy-4-phenylbutanoic acid, for ACE inhibitors.
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| fulltext | fulltext |
| identifier | ISSN: 0040-4020 |
| ispartof | Tetrahedron, 2011-08, Vol.67 (34), p.6186-6190 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Additive Additives Aliphatic compounds Asymmetric hydrogenation Asymmetry Chemistry Exact sciences and technology Hydrogenation Inhibitors Ligands Organic chemistry Preparations and properties Ruthenium SunPhos Synthesis (chemistry) Tetrahedrons α-Keto acid |
| title | Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids |
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