The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study

Two fluorescence probes for the detection of cysteine (Cys), glutathione (GSH) and other biothiols, such as homocysteine (Hcy) and cysteinyl-glycine (Cys-Gly), were developed. These molecular probes are coumarin-based derivatives containing a chalcone-like moiety that reacts with biothiols through a...

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Veröffentlicht in:	Tetrahedron letters 2011-12, Vol.52 (49), p.6606-6609
Hauptverfasser:	García-Beltrán, Olimpo, Mena, Natalia, Pérez, Edwin G., Cassels, Bruce K., Nuñez, Marco T., Werlinger, Francisca, Zavala, Daniel, Aliaga, Margarita E., Pavez, Paulina
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biothiols Chemical reactivity Chemistry Coumarin-based derivatives Cysteine Derivatives Exact sciences and technology Fluorescence Fluorescence probes Glutathione Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Interference Kinetics and mechanisms Michael addition Organic chemistry Preparations and properties Reactivity and mechanisms Tetrahedrons Thiols
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