Lewis-acid catalyzed formation of dihydropyrans

A methodology is described for the synthesis of 2,6-disubstituted dihydro[2 H]pyrans through a Lewis-acid catalyzed 6- endo- trig cyclization of β-hydroxy-γ,δ-unsaturated alcohols. Employing alkyl-substituted allylic diols and catalytic amounts of a Lewis acid, such as BF 3·OEt 2, the corresponding...

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Veröffentlicht in:	Tetrahedron 2011-12, Vol.67 (51), p.9870-9884
Hauptverfasser:	Hanessian, Stephen, Focken, Thilo, Oza, Rupal
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambient temperature Catalysis Catalysts Cyclization Cycloetherification Dihydropyran Diols Formations Heterocyclization Lewis acid Lewis-acid catalysis Synthesis (chemistry) Tetrahedrons
Online-Zugang:	Volltext
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