Bidentate ligand-catalyzed enantioselective addition of RZnX to benzaldehyde

Bidentate ligand-catalyzed enantioselective addition of RZnX to benzaldehyde

Enantioselective addition of RZnX (R=alkyl, X=Cl, OAc) was studied using chiral chelating agents, particularly metal-alkoxides. Moderate enantioselectivity was achieved in the presence of magnesium-TADDOLate using RZnOAcMg(OAc)Br as the alkylating agent.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2011-11, Vol.52 (48), p.6501-6503
Hauptverfasser: Jagtap, R.S., Joshi, N.N.
Format: Artikel
Sprache:eng
Schlagworte:
1,2-Addition
Alkylation
Asymmetric synthesis
Benzaldehyde
Chelating
Chelating ligands
Chemistry
Exact sciences and technology
Noncondensed benzenic compounds
Organic chemistry
Organozinc
Preparations and properties
Reagents
Tetrahedrons
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Beschreibung
Zusammenfassung:Enantioselective addition of RZnX (R=alkyl, X=Cl, OAc) was studied using chiral chelating agents, particularly metal-alkoxides. Moderate enantioselectivity was achieved in the presence of magnesium-TADDOLate using RZnOAcMg(OAc)Br as the alkylating agent.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.09.120