Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag

A solution-phase total synthesis of argifin using 3,4,5-tris(octadecyloxy)benzyl tag as a hydrophobic protective group of carboxylic acid was developed to produce 44% overall yield for 16 linear steps. Argifin, a novel class of natural product chitinase inhibitor, is a highly water-soluble cyclic pe...

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Veröffentlicht in:	Tetrahedron 2011-09, Vol.67 (35), p.6633-6643
Hauptverfasser:	Hirose, Tomoyasu, Kasai, Takako, Akimoto, Takafumi, Endo, Ayako, Sugawara, Akihiro, Nagasawa, Kazuo, Shiomi, Kazuro, Ōmura, Satoshi, Sunazuka, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Argifin Chemistry Chitinase inhibitor Derivatives Exact sciences and technology HO-TAGa Hydrophilic natural product Hydrophobic tag Inhibitors Methyl alcohol Natural products Noncondensed benzenic compounds Organic chemistry Peptides Preparations and properties Recrystallization Solution-phase Solvents Synthesis (chemistry) Total synthesis
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