l-Proline catalyzed synthesis of densely functionalized pyrido[2,3- d]pyrimidines via three-component one-pot domino Knoevenagel aza-Diels–Alder reaction

Highly functionalized hitherto unreported pyrido[2,3- d]pyrimidines have been concisely synthesized in good yields via l-proline catalyzed one-pot three-component domino coupling of 6-amino-1,3-dimethyluracil, aldehydes, and dialkyl acetylenedicarboxylates under mild conditions for the first time. T...

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