Microwave-assisted efficient and highly chemoselective synthesis of oxazolo[5,4-B]quinoline-fused spirooxindoles via catalyst- and solvent-free three-component tandem Knoevenagel/Michael addition reaction
[Display omitted] A microwave-assisted, chemoselective synthesis of oxazolo[5,4-b]quinoline-fused spirooxindoles have been achieved via three-component tandem Knoevenagel/Michael addition reaction of 5-amino-3-methylisoxazole, β-diketones and isatin in good to excellent yields under catalyst- and so...
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| Veröffentlicht in: | Tetrahedron letters 2015-01, Vol.56 (1), p.78-81 |
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| creator | Yuvaraj, Panneerselvam Manivannan, Karthikeyan Reddy, Boreddy S.R. |
| description | [Display omitted]
A microwave-assisted, chemoselective synthesis of oxazolo[5,4-b]quinoline-fused spirooxindoles have been achieved via three-component tandem Knoevenagel/Michael addition reaction of 5-amino-3-methylisoxazole, β-diketones and isatin in good to excellent yields under catalyst- and solvent-free conditions. The main advantages of this protocol are easiness of work-up, mild reaction and eco-friendly reaction conditions. |
| doi_str_mv | 10.1016/j.tetlet.2014.11.001 |
| format | Article |
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A microwave-assisted, chemoselective synthesis of oxazolo[5,4-b]quinoline-fused spirooxindoles have been achieved via three-component tandem Knoevenagel/Michael addition reaction of 5-amino-3-methylisoxazole, β-diketones and isatin in good to excellent yields under catalyst- and solvent-free conditions. The main advantages of this protocol are easiness of work-up, mild reaction and eco-friendly reaction conditions.</description><identifier>ISSN: 0040-4039</identifier><identifier>EISSN: 1873-3581</identifier><identifier>DOI: 10.1016/j.tetlet.2014.11.001</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Catalyst- and solvent-free ; Catalysts ; Chemoselective ; Eco-friendly ; Michael reaction ; Microwave-assisted ; Spirooxindole ; Synthesis (chemistry) ; Tandem reaction ; Tetrahedrons</subject><ispartof>Tetrahedron letters, 2015-01, Vol.56 (1), p.78-81</ispartof><rights>2014 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-73e2b20bcdf102777aaa3f83e42a3450aaf57d124a4926d910d16e3962607a953</citedby><cites>FETCH-LOGICAL-c339t-73e2b20bcdf102777aaa3f83e42a3450aaf57d124a4926d910d16e3962607a953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tetlet.2014.11.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Yuvaraj, Panneerselvam</creatorcontrib><creatorcontrib>Manivannan, Karthikeyan</creatorcontrib><creatorcontrib>Reddy, Boreddy S.R.</creatorcontrib><title>Microwave-assisted efficient and highly chemoselective synthesis of oxazolo[5,4-B]quinoline-fused spirooxindoles via catalyst- and solvent-free three-component tandem Knoevenagel/Michael addition reaction</title><title>Tetrahedron letters</title><description>[Display omitted]
A microwave-assisted, chemoselective synthesis of oxazolo[5,4-b]quinoline-fused spirooxindoles have been achieved via three-component tandem Knoevenagel/Michael addition reaction of 5-amino-3-methylisoxazole, β-diketones and isatin in good to excellent yields under catalyst- and solvent-free conditions. The main advantages of this protocol are easiness of work-up, mild reaction and eco-friendly reaction conditions.</description><subject>Catalyst- and solvent-free</subject><subject>Catalysts</subject><subject>Chemoselective</subject><subject>Eco-friendly</subject><subject>Michael reaction</subject><subject>Microwave-assisted</subject><subject>Spirooxindole</subject><subject>Synthesis (chemistry)</subject><subject>Tandem reaction</subject><subject>Tetrahedrons</subject><issn>0040-4039</issn><issn>1873-3581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFSEQhTtGE6-jb-CCpQvpgYb-25joxL84xo2ujCE1UExzQ8OdhtvO9Rl9KGmva1lALc45VcVXVc85qznj3eW-zpg95rphXNac14zxB9WOD72goh34w2rHmGRUMjE-rp6ktGfldAPbVb8_O73En7AihZRcymgIWuu0w5AJBEMmdzv5E9ETzjGhR53diiSdQp6wGEi0JN7Dr-jj9_alpG9-3B1diN4FpPaYSlw6uCXGexdM9JjI6oBoyOBPKdO_HVL0a-lG7YJI8lRuquN8iGEbIRcFzuRTiFhEcIv-sow8AXoCxrjsYiALgt6Kp9UjCz7hs3_vRfXt3duvVx_o9Zf3H69eX1MtxJhpL7C5adiNNpazpu97ABB2ECgbELJlALbtDW8kyLHpzMiZ4R2KsWs61sPYiovqxTn3sMS7I6asZpc0eg8B4zEp3kvZ9W0zjEUqz9LyyyktaNVhcTMsJ8WZ2uCpvTrDUxs8xbkq8Irt1dmGZY3V4aLSRkSjcUshoEx0_w_4A_pUqzk</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Yuvaraj, Panneerselvam</creator><creator>Manivannan, Karthikeyan</creator><creator>Reddy, Boreddy S.R.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20150101</creationdate><title>Microwave-assisted efficient and highly chemoselective synthesis of oxazolo[5,4-B]quinoline-fused spirooxindoles via catalyst- and solvent-free three-component tandem Knoevenagel/Michael addition reaction</title><author>Yuvaraj, Panneerselvam ; Manivannan, Karthikeyan ; Reddy, Boreddy S.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-73e2b20bcdf102777aaa3f83e42a3450aaf57d124a4926d910d16e3962607a953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Catalyst- and solvent-free</topic><topic>Catalysts</topic><topic>Chemoselective</topic><topic>Eco-friendly</topic><topic>Michael reaction</topic><topic>Microwave-assisted</topic><topic>Spirooxindole</topic><topic>Synthesis (chemistry)</topic><topic>Tandem reaction</topic><topic>Tetrahedrons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuvaraj, Panneerselvam</creatorcontrib><creatorcontrib>Manivannan, Karthikeyan</creatorcontrib><creatorcontrib>Reddy, Boreddy S.R.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Tetrahedron letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuvaraj, Panneerselvam</au><au>Manivannan, Karthikeyan</au><au>Reddy, Boreddy S.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microwave-assisted efficient and highly chemoselective synthesis of oxazolo[5,4-B]quinoline-fused spirooxindoles via catalyst- and solvent-free three-component tandem Knoevenagel/Michael addition reaction</atitle><jtitle>Tetrahedron letters</jtitle><date>2015-01-01</date><risdate>2015</risdate><volume>56</volume><issue>1</issue><spage>78</spage><epage>81</epage><pages>78-81</pages><issn>0040-4039</issn><eissn>1873-3581</eissn><abstract>[Display omitted]
A microwave-assisted, chemoselective synthesis of oxazolo[5,4-b]quinoline-fused spirooxindoles have been achieved via three-component tandem Knoevenagel/Michael addition reaction of 5-amino-3-methylisoxazole, β-diketones and isatin in good to excellent yields under catalyst- and solvent-free conditions. The main advantages of this protocol are easiness of work-up, mild reaction and eco-friendly reaction conditions.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.tetlet.2014.11.001</doi><tpages>4</tpages></addata></record> |
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| ispartof | Tetrahedron letters, 2015-01, Vol.56 (1), p.78-81 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Catalyst- and solvent-free Catalysts Chemoselective Eco-friendly Michael reaction Microwave-assisted Spirooxindole Synthesis (chemistry) Tandem reaction Tetrahedrons |
| title | Microwave-assisted efficient and highly chemoselective synthesis of oxazolo[5,4-B]quinoline-fused spirooxindoles via catalyst- and solvent-free three-component tandem Knoevenagel/Michael addition reaction |
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