Copper-catalyzed chalcogenoamination of 2-alkynylanilines with dichalcogenides for one-step synthesis of 3-sulfenylindoles and 3-selenylindoles

The copper-catalyzed chalcogenoamination of 2-alkynylanilines with dichalcogenides has been established, providing a convenient and efficient method for synthesis of 3-sulfenylindoles and 3-selenylindoles, including complex products bearing two attached 3-sulfenylindole rings. The copper-catalyzed c...

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Veröffentlicht in:	Tetrahedron letters 2011-03, Vol.52 (12), p.1343-1347
Hauptverfasser:	Li, Zhen, Hong, Longcheng, Liu, Ruiting, Shen, Jianzhong, Zhou, Xigeng
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Alkynylaniline 3-Chalcogenylindole Bearing Chemistry Copper(I) iodide Dichalcogenides Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Noncondensed benzenic compounds Organic chemistry Oxidants Oxidizing agents Preparations and properties Synthesis (chemistry) Tetrahedrons
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Beschreibung
Zusammenfassung:	The copper-catalyzed chalcogenoamination of 2-alkynylanilines with dichalcogenides has been established, providing a convenient and efficient method for synthesis of 3-sulfenylindoles and 3-selenylindoles, including complex products bearing two attached 3-sulfenylindole rings. The copper-catalyzed chalcogenoamination of 2-alkynylanilines with dichalcogenides has been achieved under mild reaction conditions using the weak base Cs 2CO 3 in combination with air oxidant, providing a convenient and efficient method for synthesis of 3-sulfenylindoles and 3-selenylindoles, including complex products bearing two attached 3-sulfenylindole rings.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.01.052