Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients

Initial triggers for diabetic retinopathy (DR) are hyperglycemia-induced oxidative stress and advanced glycation end-products. The most pathological structural changes occur in retinal microvasculature, but the overall development of DR is multifactorial, with a complex interplay of microvascular, n...

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Veröffentlicht in:	Journal of proteome research 2015-12, Vol.14 (12), p.5131-5143
Hauptverfasser:	Loukovaara, Sirpa, Nurkkala, Helka, Tamene, Fitsum, Gucciardo, Erika, Liu, Xiaonan, Repo, Pauliina, Lehti, Kaisa, Varjosalo, Markku
Format:	Artikel
Sprache:	eng
Schlagworte:	Bevacizumab - therapeutic use Chromatography, Liquid Diabetic Retinopathy - drug therapy Diabetic Retinopathy - metabolism Humans Mass Spectrometry - methods Proteome - analysis Proteomics - methods Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Vitreous Body - metabolism Vitreous Body - pathology
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