Synergistic Effect of Hydrogen Peroxide and Elastase on Elastic Fiber Injury In Vitro

This laboratory has previously shown that hyperoxia enhances airspace enlargement in a hamster model of elastase-induced emphysema. To further understand the mechanism responsible for this finding, the effect of oxidants on elastase activity was studied in vitro, using a radiolabeled elastic fiber m...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2006-01, Vol.231 (1), p.107-111
Hauptverfasser:	Cantor, Jerome O., Shteyngart, Bronislava, Cerreta, Joseph M., Ma, Shuren, Turino, Gerard M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Desmosine - metabolism Drug Synergism Elastic Tissue - drug effects Elastic Tissue - injuries Elastic Tissue - metabolism Extracellular Matrix - drug effects Extracellular Matrix - metabolism Hydrogen Peroxide - toxicity Inflammation Mediators - metabolism Isodesmosine - metabolism Isotope Labeling Oxidants - pharmacology Oxidants - toxicity Pancreatic Elastase - toxicity Pleural Neoplasms - metabolism Pleural Neoplasms - pathology Pulmonary Emphysema - chemically induced Pulmonary Emphysema - metabolism Pulmonary Emphysema - pathology Rats Time Factors
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