Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells

In rat type I astrocytes and C6 glioma cells, sphingosine 1-phosphate (S1P) clearly induced the expression of fibroblast growth factor-2 (FGF-2) mRNA to an extent comparable to that achieved by platelet-derived growth factor (PDGF) and endothelin. In C6 cells, Western blotting showed that S1P also i...

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Veröffentlicht in:	Brain research. Molecular brain research. 1999-12, Vol.74 (1), p.182-189
Hauptverfasser:	Sato, Koichi, Ishikawa, Koichi, Ui, Michio, Okajima, Fumikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Cells, Cultured DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - drug effects Early Growth Response Protein 1 Early growth response-1 Endothelins - pharmacology extracellular signal-regulated kinase Fibroblast Growth Factor 2 - genetics Fibroblast growth factor-2 Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Glioma - metabolism Glioma - pathology GTP-binding protein GTP-Binding Proteins - metabolism Immediate-Early Proteins Isolated neuron and nerve. Neuroglia Lysophospholipids Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - physiology Naphthalenes - pharmacology Pertussis Toxin Platelet-Derived Growth Factor - pharmacology Protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Rats RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine 1-phosphate Tetradecanoylphorbol Acetate - pharmacology Transcription Factors - biosynthesis Transcription Factors - drug effects Tumor Cells, Cultured Vertebrates: nervous system and sense organs Virulence Factors, Bordetella - pharmacology
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