Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats

Several lines of evidence have suggested that the glutamatergic system in the nucleus accumbens (NAc) plays an important role in the conditioned rewarding effect of drugs of abuse. In addition, it is recognized that extracellular glutamate is rapidly removed from the synaptic cleft by Na+‐dependent...

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Veröffentlicht in:	The European journal of neuroscience 2005-12, Vol.22 (11), p.2744-2754
Hauptverfasser:	Fujio, Mayumi, Nakagawa, Takayuki, Sekiya, Yumiko, Ozawa, Tohru, Suzuki, Yuichi, Minami, Masabumi, Satoh, Masamichi, Kaneko, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics adenovirus Animals astrocyte Blotting, Western Central Nervous System Stimulants - pharmacology Conditioning, Operant - drug effects Excitatory Amino Acid Transporter 2 - genetics Gene Transfer Techniques glutamate uptake Male mesolimbic dopaminergic system Methamphetamine - pharmacology Morphine - pharmacology Morphine Dependence - genetics Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Nucleus Accumbens - metabolism Nucleus Accumbens - physiology Rats Rats, Sprague-Dawley rewarding
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