Drastic Ca super(2) super(+) sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy

Six missense mutations in human cardiac troponin I (cTnI) were recently found to cause restrictive cardiomyopathy (RCM). We have bacterially expressed and purified these human cTnI mutants and examined their functional and structural consequences. Inserting the human cTnI into skinned cardiac muscle...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical and biophysical research communications 2005-12, Vol.338 (3), p.1519-1526
Hauptverfasser:	Yumoto, F, Lu, Q W, Morimoto, S, Tanaka, H, Kono, N, Nagata, K, Ojima, T, Takahashi-Yanaga, F, Miwa, Y, Sasaguri, T, Nishita, K, Tanokura, M, Ohtsuki, I
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!