Induction of glutamate-cysteine ligase (γ-glutamylcysteine synthetase) in the brains of adult female mice subchronically exposed to methylmercury

Methylmercury (MeHg) is widely known for its potent neurotoxic properties. One proposed mechanism of action of MeHg relates to its high affinity for sulfhydryl groups, especially those found on glutathione (GSH) and proteins. Previous studies have shown that acute MeHg exposure results in an increas...

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Veröffentlicht in:	Toxicology letters 1999-10, Vol.110 (1), p.1-9
Hauptverfasser:	Thompson, Sally A, White, Collin C, Krejsa, Cecile M, Diaz, Dolores, Woods, James S, Eaton, David L, Kavanagh, Terrance J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Blotting, Western Brain - drug effects Brain - enzymology Chemical and industrial products toxicology. Toxic occupational diseases Chromatography, High Pressure Liquid dimethylmercury Enzyme Induction Female Glutamate-cysteine ligase Glutamate-Cysteine Ligase - biosynthesis Glutathione Glutathione - metabolism Kidney - drug effects Kidney - enzymology Liver - drug effects Liver - enzymology Medical sciences Metals and various inorganic compounds Methylmercury Methylmercury Compounds - toxicity Mice Mice, Inbred C57BL Oxidation-Reduction Toxicology γ-Glutamylcysteine synthetase
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