Mutagenesis rescues spermine and Zn2+ potentiation of recombinant NMDA receptors

Alternative splicing generates distinct forms of the NMDA receptor subunit NR1. NR1 subunits with an N-terminal insert (termed N1) form receptors in Xenopus oocytes with greatly reduced potentiation by spermine and Zn2+. Oocytes expressing NR1 receptors with N1 exhibited larger NMDA currents than oo...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1994-04, Vol.12 (4), p.811-818
Hauptverfasser:	Zheng, X, Zhang, L, Durand, G M, Bennett, M V, Zukin, R S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Drug Synergism Electrophysiology Female Glycine - pharmacology Molecular Sequence Data Mutagenesis, Site-Directed N-Methylaspartate - pharmacology Oocytes - metabolism Receptors, N-Methyl-D-Aspartate - chemistry Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - physiology Recombinant Proteins - metabolism spermine Spermine - pharmacology Transfection Xenopus Zinc - pharmacology
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