Diverse Karyotypic Abnormalities of the c-myc Locus Associated with c-myc Dysregulation and Tumor Progression in Multiple Myeloma

Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary...

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