Isolation of a funnel-web spider polypeptide with homology to mamba intestinal toxin 1 and the embryonic head inducer Dickkopf-1

We have isolated and determined the amino acid sequence of a novel peptide component from the venom of the Australian funnel-web spider Hadronyche versuta. This 68-residue toxin, ACTX-Hvf17, does not function like classical neurotoxins in modulating ion channel function as evidenced by its lack of i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicon (Oxford) 2000-03, Vol.38 (3), p.429-442
Hauptverfasser:	Szeto, Tim H, Wang, Xiu-hong, Smith, Ross, Connor, Mark, Christie, Macdonald J, Nicholson, Graham M, King, Glenn F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acheta domesticus Amino Acid Sequence amino acid sequences Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Chickens chicks Chromatography, High Pressure Liquid colipases Cysteine - analysis dendroaspis polylepis polylepis Dickkopf-1 gene Disulfides - analysis enzyme activity Female Freeze Drying Gryllidae Hadronyche versuta Hexathelidae In Vitro Techniques Male Medical sciences Molecular Sequence Data muscle contraction Muscle, Smooth - drug effects Muscle, Smooth - innervation Oxidation-Reduction Peptides - chemistry Peptides - isolation & purification Peptides - toxicity polypeptides proteins Proteins - chemistry Proteins - isolation & purification Rats Sequence Homology, Amino Acid skeletal muscle smooth muscle species differences Spider Venoms - chemistry Spider Venoms - isolation & purification Spiders - metabolism swissprot/p81803 toxicity Toxicology toxins triacylglycerol lipase Vas Deferens - drug effects Vas Deferens - innervation venoms Venoms - chemistry Venoms - isolation & purification Viperidae
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!