A model to evaluate the biological effect of natural products: vincristine action on the biodistribution of radiopharmaceuticals in balb/c female mice

Natural products have been widely used by human beings. However, sometimes the biological effects of these products are not fully known. We are trying to develop a model to evaluate the toxicity of compounds employed as therapeutic drugs. This model is based on the capability of natural products to...

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Veröffentlicht in:Journal of applied toxicology 1999-07, Vol.19 (4), p.251-254
Hauptverfasser: Mattos, Deise Mara M., Gomes, Maria Luisa, Freitas, Rosimeire S., Rodrigues, Pedro Carvalho, Paula, Emílio F., Bernardo-Filho, Mario
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container_end_page 254
container_issue 4
container_start_page 251
container_title Journal of applied toxicology
container_volume 19
creator Mattos, Deise Mara M.
Gomes, Maria Luisa
Freitas, Rosimeire S.
Rodrigues, Pedro Carvalho
Paula, Emílio F.
Bernardo-Filho, Mario
description Natural products have been widely used by human beings. However, sometimes the biological effects of these products are not fully known. We are trying to develop a model to evaluate the toxicity of compounds employed as therapeutic drugs. This model is based on the capability of natural products to alter the biodistribution of radiopharmaceuticals labelled with technetium‐99m (99mTc). The acceptance of 99mTc‐labelled radiopharmaceuticals is so rapid and its current use so diverse that it is not possible to study this radionuclide’s behaviour in the body more deeply. There is evidence that the biodistribution or the pharmacokinetics of radiopharmaceuticals can be modified by some drugs, by pathological states, by irradiation and by surgical procedures. A lack of knowledge of such factors can induce a misvisualization of the scintigraphic images, leading to a misdiagnosis. Vincristine is a natural product that has been employed in various chemotherapeutic protocols in oncology. We have studied the effect of vincristine on the distribution of [99mTc]methylenediphosphonic acid ([99mTc]MDP) in female mice. After the last dose of vincristine, [99mTc]MDP was injected, the animals were sacrificed and the percentage of radioactivity (%ATI) was determined in the isolated organs. The %ATI was significantly decreased in the uterus, ovary, spleen, thymus, lymph nodes (inguinal and mesentheric), kidney, liver, pancreas, stomach, heart, brain and bone of the animals treated with the natural product. Several biological effects have been reported in patients treated with vincristine. These effects could justify the alterations in the uptake of the radiopharmaceutical in specific organs. Moreover, these results have shown that it is possible to employ this model to evaluate the toxicity of drugs. Copyright © 1999 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/(SICI)1099-1263(199907/08)19:4<251::AID-JAT575>3.0.CO;2-Y
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Appl. Toxicol</addtitle><description>Natural products have been widely used by human beings. However, sometimes the biological effects of these products are not fully known. We are trying to develop a model to evaluate the toxicity of compounds employed as therapeutic drugs. This model is based on the capability of natural products to alter the biodistribution of radiopharmaceuticals labelled with technetium‐99m (99mTc). The acceptance of 99mTc‐labelled radiopharmaceuticals is so rapid and its current use so diverse that it is not possible to study this radionuclide’s behaviour in the body more deeply. There is evidence that the biodistribution or the pharmacokinetics of radiopharmaceuticals can be modified by some drugs, by pathological states, by irradiation and by surgical procedures. A lack of knowledge of such factors can induce a misvisualization of the scintigraphic images, leading to a misdiagnosis. Vincristine is a natural product that has been employed in various chemotherapeutic protocols in oncology. We have studied the effect of vincristine on the distribution of [99mTc]methylenediphosphonic acid ([99mTc]MDP) in female mice. After the last dose of vincristine, [99mTc]MDP was injected, the animals were sacrificed and the percentage of radioactivity (%ATI) was determined in the isolated organs. The %ATI was significantly decreased in the uterus, ovary, spleen, thymus, lymph nodes (inguinal and mesentheric), kidney, liver, pancreas, stomach, heart, brain and bone of the animals treated with the natural product. Several biological effects have been reported in patients treated with vincristine. These effects could justify the alterations in the uptake of the radiopharmaceutical in specific organs. Moreover, these results have shown that it is possible to employ this model to evaluate the toxicity of drugs. 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subjects [99mtc]mdp
Animals
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
drug interaction
Drug toxicity and drugs side effects treatment
Female
Lung - drug effects
Lung - metabolism
Medical sciences
Mice
Mice, Inbred BALB C
Miscellaneous (drug allergy, mutagens, teratogens...)
Models, Biological
natural product
natural products
Pharmacology. Drug treatments
Radiopharmaceuticals - pharmacokinetics
Technetium Tc 99m Medronate - pharmacokinetics
Thyroid Gland - drug effects
Thyroid Gland - metabolism
Tissue Distribution - drug effects
vincristine
Vincristine - pharmacology
title A model to evaluate the biological effect of natural products: vincristine action on the biodistribution of radiopharmaceuticals in balb/c female mice
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