Role of Inflammatory Infiltrate in Activation and Effector Function of Cloned Islet Reactive Nonobese Diabetic CD8 super(+) T Cells: Involvement of a Nitric Oxide-Dependent Pathway

To investigate how CD8 super(+) T cells interact with beta cells and local inflammatory cells in islets, we have isolated CD8 super(+) T cell clones from nonobese diabetic (NOD) spleen that recognize and destroy both islets and the NOD insulinoma cell line NIT-1. The clones destroyed NOD islets with...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-12, Vol.163 (11), p.5770-5780
Hauptverfasser:	Gurlo, T, Kawamura, K, von Grafenstein, H
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8 antigen
Online-Zugang:	Volltext
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