Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships

Hannoa chlorantha and Hannoa klaineana (Simaroubaceae) are used in traditional medicine of Central African countries against fevers and malaria. Four stem bark extracts from H. klaineana and four quassinoids from H. chlorantha were examined in vitro against Plasmodium falciparum NF 54. The extracts...

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Veröffentlicht in:	International journal for parasitology 1998-04, Vol.28 (4), p.635-640
Hauptverfasser:	François, Guido, Diakanamwa, Carlos, Timperman, Georges, Bringmann, Gerhard, Steenackers, Tania, Atassi, Ghanem, Van Looveren, Marleen, Holenz, Jörg, Tassin, Jean-Pierre, AkéAssi, Laurent, Vanhaelen-Fastré, Renée, Vanhaelen, Maurice
Format:	Artikel
Sprache:	eng
Schlagworte:	14-Hydroxychaparrinone 15-Desacetylundulatone Animals Antimalarials - chemistry Antimalarials - pharmacology Antimalarials - toxicity Biological and medical sciences Cell Survival - drug effects chaparrinone Cytotoxicity Female General pharmacology Glaucarubin - analogs & derivatives Glaucarubin - chemistry Glaucarubin - pharmacology Glaucarubin - toxicity Hannoa chlorantha Hannoa klaineana Leukemia P388 Malaria Malaria - drug therapy Medical sciences Mice P-388 cells Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - toxicity Plant Roots - chemistry Plants, Medicinal - chemistry Plasmodium berghei - drug effects Plasmodium berghei in vivo Plasmodium falciparum - drug effects Plasmodium falciparum in vitro Quassinoids Quassins Seeds - chemistry Simaroubaceae Structure-Activity Relationship Tumor Cells, Cultured
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