Expression of the human α:1,2‐fucosyltransferase in transgenic pigs modifies the cell surface carbohydrate phenotype and confers resistance to human serum‐mediated cytolysis

ABSTRACTHyperacute rejection (HAR) is the first critical immunological hurdle that must be addressed in order to develop xenogeneic organs for human transplantation. In the area of cell‐based xenotransplant therapies, natural antibodies (XNA) and complement have also been considered barriers to succ...

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Veröffentlicht in:	The FASEB journal 1999-10, Vol.13 (13), p.1762-1773
Hauptverfasser:	Costa, Cristina, Zhao, Lisa, Burton, Willis V., Bondioli, Kenneth R, Williams, Barry L., Hoagland, Thomas A., Ditullio, Paul A., Ebert, Karl M., Fodor, William L.
Format:	Artikel
Sprache:	eng
Schlagworte:	a-1,2-fucosyltransferase delayed xenograft rejection hyperacute rejection H‐transferase xenotransplantation
Online-Zugang:	Volltext
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