Tn 5 : A Molecular Window on Transposition
DNA transposition is an underlying process involved in the remodeling of genomes in all types of organisms. We analyze the multiple steps in cut-and-paste transposition using the bacterial transposon Tn5 as a model. This system is particularly illuminating because of the existence of structural, gen...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1999-12, Vol.266 (3), p.729-734 |
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| container_end_page | 734 |
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| container_issue | 3 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 266 |
| creator | Reznikoff, W S Bhasin, A Davies, DR Goryshin, I Y Mahnke, LA Naumann, T Rayment, I Steiniger-White, M Twining, S S |
| description | DNA transposition is an underlying process involved in the remodeling of genomes in all types of organisms. We analyze the multiple steps in cut-and-paste transposition using the bacterial transposon Tn5 as a model. This system is particularly illuminating because of the existence of structural, genetic, and biochemical information regarding the two participating specific macromolecules: the transposase and the 19-bp sequences that define the ends of the transposon. However, most of the insights should be of general interest because of similarities to other transposition-like systems such as HIV-1 DNA integration into the host genome. |
| doi_str_mv | 10.1006/bbrc.1999.1891 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1999-12, Vol.266 (3), p.729-734 |
| issn | 0006-291X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17426703 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Human immunodeficiency virus 1 transposase transposon Tn5 |
| title | Tn 5 : A Molecular Window on Transposition |
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