Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8 super(+) cells by the hydroxylamine of sulfamethoxazole

Treatment with sulfonamide antibiotics in HIV-infected patients is associated with a high incidence (> 40%) of adverse drug events, including severe hypersensitivity reactions. Sulfonamide reactive metabolites have been implicated in the pathogenesis of these adverse reactions. Sulfamethoxazole h...

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Veröffentlicht in:	The FASEB journal 1999-10, Vol.13 (13), p.1688-1698
Hauptverfasser:	Hess, DA, Sisson, ME, Suria, H, Wijsman, J, Puvanesasingham, R, Madrenas, J, Rieder, MJ
Format:	Artikel
Sprache:	eng
Schlagworte:	sulfamethoxazole hydroxylamine sulfonamides
Online-Zugang:	Volltext
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