The Effects of the Naltrexone Implant on Rodent Social Interactions and Cocaine-Induced Conditioned Place Preference
Two experiments were conducted to determine the behavioral properties of the naltrexone implant on: 1) rodent social interactions; and 2) the appetitive properties of cocaine. Rats were surgically implanted with a naltrexone implant (placebo, 10 or 30 mg) and placed into an open field for the record...
Gespeichert in:
| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1999-01, Vol.62 (1), p.97-102 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 102 |
|---|---|
| container_issue | 1 |
| container_start_page | 97 |
| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 62 |
| creator | Mitchem, Leanne D. Kruschel, C.K. Dallman, E. Anders, Katie A. Czapiga, Megan Panos, John J. Steinpreis, Rhea E. |
| description | Two experiments were conducted to determine the behavioral properties of the naltrexone implant on: 1) rodent social interactions; and 2) the appetitive properties of cocaine. Rats were surgically implanted with a naltrexone implant (placebo, 10 or 30 mg) and placed into an open field for the recording of social interactions. The naltrexone implants increased latency to initiate contact and decreased pinning, bouts of grooming, and crawl unders on all 7 days. Other rats were surgically implanted with naltrexone (60, 120, or 240 mg) and habituated to a two-chambered conditioned place preference apparatus. After 6 days of conditioning, place preference was computer recorded. Cocaine produced a dose-dependent conditioned place preference in the rats implanted with placebo or 60 mg of naltrexone. The 120 and 240 mg naltrexone implants blocked the emergence of cocaine-induced place preference. The results indicate that naltrexone implants produce significant social behavioral effects within 1 day, and are effective at attenuating the conditioned place preference produced by cocaine. |
| doi_str_mv | 10.1016/S0091-3057(98)00150-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17426395</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091305798001506</els_id><sourcerecordid>17426395</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-e2b2ac871dda4e293183d5e4fe14ecdd9e43c1481ba31e2a3f446f74fb8ea24d3</originalsourceid><addsrcrecordid>eNqFkU1vEzEQhi0EKqHwEyr5gBAcFvy1690TqqICkSqoaDlbE3ssjDZ2sB0E_x5vE5UjJ8_ofefrMSEXnL3ljA_vbhmbeCdZr19P4xvGeM-64RFZ8VHLrudaPyarB8tT8qyUH4wxJQZ9Rs6mSYux5ytS774jvfIebS00eVpb-hnmmvF3ikg3u_0MsdIU6dfksEW3yQaY6SZWzGBrSLFQiI6uk4UQsdtEd7C45NGFRW7xzQwW6U1GjxmjxefkiYe54IvTe06-fbi6W3_qrr983KwvrzurBKsdiq0AO2ruHCgUk-SjdD0qj1yhdW5CJS1XI9-C5ChAeqUGr5XfjghCOXlOXh377nP6ecBSzS4Ui3M7CdOhGK4bDjn1zdgfjTanUtqeZp_DDvIfw5lZaJt72mZBaabR3NM2Q6u7OA04bHfoHqpOeJv-8qRDsTD7DNGG8q_5IHrFl_HvjzZsMH4FzKbYsIByIbePMS6F_yzyF0arnO8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17426395</pqid></control><display><type>article</type><title>The Effects of the Naltrexone Implant on Rodent Social Interactions and Cocaine-Induced Conditioned Place Preference</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Mitchem, Leanne D. ; Kruschel, C.K. ; Dallman, E. ; Anders, Katie A. ; Czapiga, Megan ; Panos, John J. ; Steinpreis, Rhea E.</creator><creatorcontrib>Mitchem, Leanne D. ; Kruschel, C.K. ; Dallman, E. ; Anders, Katie A. ; Czapiga, Megan ; Panos, John J. ; Steinpreis, Rhea E.</creatorcontrib><description>Two experiments were conducted to determine the behavioral properties of the naltrexone implant on: 1) rodent social interactions; and 2) the appetitive properties of cocaine. Rats were surgically implanted with a naltrexone implant (placebo, 10 or 30 mg) and placed into an open field for the recording of social interactions. The naltrexone implants increased latency to initiate contact and decreased pinning, bouts of grooming, and crawl unders on all 7 days. Other rats were surgically implanted with naltrexone (60, 120, or 240 mg) and habituated to a two-chambered conditioned place preference apparatus. After 6 days of conditioning, place preference was computer recorded. Cocaine produced a dose-dependent conditioned place preference in the rats implanted with placebo or 60 mg of naltrexone. The 120 and 240 mg naltrexone implants blocked the emergence of cocaine-induced place preference. The results indicate that naltrexone implants produce significant social behavioral effects within 1 day, and are effective at attenuating the conditioned place preference produced by cocaine.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(98)00150-6</identifier><identifier>PMID: 9972851</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Addiction ; Animals ; Biological and medical sciences ; Cocaine ; Cocaine - pharmacology ; Conditioned place preference ; Conditioning (Psychology) - drug effects ; Drug addictions ; Drug Implants ; Drug Interactions ; Grooming - drug effects ; Male ; Medical sciences ; Motor Activity - drug effects ; naltrexone ; Naltrexone - pharmacology ; Naltrexone implants ; Narcotic Antagonists - pharmacology ; Rats ; Rats, Sprague-Dawley ; Social Behavior ; Toxicology</subject><ispartof>Pharmacology, biochemistry and behavior, 1999-01, Vol.62 (1), p.97-102</ispartof><rights>1999 Elsevier Science Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-e2b2ac871dda4e293183d5e4fe14ecdd9e43c1481ba31e2a3f446f74fb8ea24d3</citedby><cites>FETCH-LOGICAL-c420t-e2b2ac871dda4e293183d5e4fe14ecdd9e43c1481ba31e2a3f446f74fb8ea24d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(98)00150-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1625415$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9972851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitchem, Leanne D.</creatorcontrib><creatorcontrib>Kruschel, C.K.</creatorcontrib><creatorcontrib>Dallman, E.</creatorcontrib><creatorcontrib>Anders, Katie A.</creatorcontrib><creatorcontrib>Czapiga, Megan</creatorcontrib><creatorcontrib>Panos, John J.</creatorcontrib><creatorcontrib>Steinpreis, Rhea E.</creatorcontrib><title>The Effects of the Naltrexone Implant on Rodent Social Interactions and Cocaine-Induced Conditioned Place Preference</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Two experiments were conducted to determine the behavioral properties of the naltrexone implant on: 1) rodent social interactions; and 2) the appetitive properties of cocaine. Rats were surgically implanted with a naltrexone implant (placebo, 10 or 30 mg) and placed into an open field for the recording of social interactions. The naltrexone implants increased latency to initiate contact and decreased pinning, bouts of grooming, and crawl unders on all 7 days. Other rats were surgically implanted with naltrexone (60, 120, or 240 mg) and habituated to a two-chambered conditioned place preference apparatus. After 6 days of conditioning, place preference was computer recorded. Cocaine produced a dose-dependent conditioned place preference in the rats implanted with placebo or 60 mg of naltrexone. The 120 and 240 mg naltrexone implants blocked the emergence of cocaine-induced place preference. The results indicate that naltrexone implants produce significant social behavioral effects within 1 day, and are effective at attenuating the conditioned place preference produced by cocaine.</description><subject>Addiction</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Conditioned place preference</subject><subject>Conditioning (Psychology) - drug effects</subject><subject>Drug addictions</subject><subject>Drug Implants</subject><subject>Drug Interactions</subject><subject>Grooming - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>naltrexone</subject><subject>Naltrexone - pharmacology</subject><subject>Naltrexone implants</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Social Behavior</subject><subject>Toxicology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EKqHwEyr5gBAcFvy1690TqqICkSqoaDlbE3ssjDZ2sB0E_x5vE5UjJ8_ofefrMSEXnL3ljA_vbhmbeCdZr19P4xvGeM-64RFZ8VHLrudaPyarB8tT8qyUH4wxJQZ9Rs6mSYux5ytS774jvfIebS00eVpb-hnmmvF3ikg3u_0MsdIU6dfksEW3yQaY6SZWzGBrSLFQiI6uk4UQsdtEd7C45NGFRW7xzQwW6U1GjxmjxefkiYe54IvTe06-fbi6W3_qrr983KwvrzurBKsdiq0AO2ruHCgUk-SjdD0qj1yhdW5CJS1XI9-C5ChAeqUGr5XfjghCOXlOXh377nP6ecBSzS4Ui3M7CdOhGK4bDjn1zdgfjTanUtqeZp_DDvIfw5lZaJt72mZBaabR3NM2Q6u7OA04bHfoHqpOeJv-8qRDsTD7DNGG8q_5IHrFl_HvjzZsMH4FzKbYsIByIbePMS6F_yzyF0arnO8</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Mitchem, Leanne D.</creator><creator>Kruschel, C.K.</creator><creator>Dallman, E.</creator><creator>Anders, Katie A.</creator><creator>Czapiga, Megan</creator><creator>Panos, John J.</creator><creator>Steinpreis, Rhea E.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope></search><sort><creationdate>199901</creationdate><title>The Effects of the Naltrexone Implant on Rodent Social Interactions and Cocaine-Induced Conditioned Place Preference</title><author>Mitchem, Leanne D. ; Kruschel, C.K. ; Dallman, E. ; Anders, Katie A. ; Czapiga, Megan ; Panos, John J. ; Steinpreis, Rhea E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-e2b2ac871dda4e293183d5e4fe14ecdd9e43c1481ba31e2a3f446f74fb8ea24d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Addiction</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Conditioned place preference</topic><topic>Conditioning (Psychology) - drug effects</topic><topic>Drug addictions</topic><topic>Drug Implants</topic><topic>Drug Interactions</topic><topic>Grooming - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>naltrexone</topic><topic>Naltrexone - pharmacology</topic><topic>Naltrexone implants</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Social Behavior</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitchem, Leanne D.</creatorcontrib><creatorcontrib>Kruschel, C.K.</creatorcontrib><creatorcontrib>Dallman, E.</creatorcontrib><creatorcontrib>Anders, Katie A.</creatorcontrib><creatorcontrib>Czapiga, Megan</creatorcontrib><creatorcontrib>Panos, John J.</creatorcontrib><creatorcontrib>Steinpreis, Rhea E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitchem, Leanne D.</au><au>Kruschel, C.K.</au><au>Dallman, E.</au><au>Anders, Katie A.</au><au>Czapiga, Megan</au><au>Panos, John J.</au><au>Steinpreis, Rhea E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of the Naltrexone Implant on Rodent Social Interactions and Cocaine-Induced Conditioned Place Preference</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1999-01</date><risdate>1999</risdate><volume>62</volume><issue>1</issue><spage>97</spage><epage>102</epage><pages>97-102</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Two experiments were conducted to determine the behavioral properties of the naltrexone implant on: 1) rodent social interactions; and 2) the appetitive properties of cocaine. Rats were surgically implanted with a naltrexone implant (placebo, 10 or 30 mg) and placed into an open field for the recording of social interactions. The naltrexone implants increased latency to initiate contact and decreased pinning, bouts of grooming, and crawl unders on all 7 days. Other rats were surgically implanted with naltrexone (60, 120, or 240 mg) and habituated to a two-chambered conditioned place preference apparatus. After 6 days of conditioning, place preference was computer recorded. Cocaine produced a dose-dependent conditioned place preference in the rats implanted with placebo or 60 mg of naltrexone. The 120 and 240 mg naltrexone implants blocked the emergence of cocaine-induced place preference. The results indicate that naltrexone implants produce significant social behavioral effects within 1 day, and are effective at attenuating the conditioned place preference produced by cocaine.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9972851</pmid><doi>10.1016/S0091-3057(98)00150-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1999-01, Vol.62 (1), p.97-102 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17426395 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Addiction Animals Biological and medical sciences Cocaine Cocaine - pharmacology Conditioned place preference Conditioning (Psychology) - drug effects Drug addictions Drug Implants Drug Interactions Grooming - drug effects Male Medical sciences Motor Activity - drug effects naltrexone Naltrexone - pharmacology Naltrexone implants Narcotic Antagonists - pharmacology Rats Rats, Sprague-Dawley Social Behavior Toxicology |
| title | The Effects of the Naltrexone Implant on Rodent Social Interactions and Cocaine-Induced Conditioned Place Preference |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T03%3A56%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effects%20of%20the%20Naltrexone%20Implant%20on%20Rodent%20Social%20Interactions%20and%20Cocaine-Induced%20Conditioned%20Place%20Preference&rft.jtitle=Pharmacology,%20biochemistry%20and%20behavior&rft.au=Mitchem,%20Leanne%20D.&rft.date=1999-01&rft.volume=62&rft.issue=1&rft.spage=97&rft.epage=102&rft.pages=97-102&rft.issn=0091-3057&rft.eissn=1873-5177&rft.coden=PBBHAU&rft_id=info:doi/10.1016/S0091-3057(98)00150-6&rft_dat=%3Cproquest_cross%3E17426395%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17426395&rft_id=info:pmid/9972851&rft_els_id=S0091305798001506&rfr_iscdi=true |